Aphasia Neuroplasticity Review

Supplementary Table S15. Cross-sectional performance-defined conditions: Methodologically robust analyses

AnalysisFirst level contrastSecond level contrastMatched forStatsNotesFindings
AccRT
Fridriksson et al. (2009):
Vox 2
Picture naming (phonemic paraphasias) vs picture naming (correct trials) CB
Aphasia
NBD UNR Vox
C-
Search volume: voxels spared in all patients; software: FSL (FEAT 5.4); voxelwise p: ~.01 (z > 2.3); cluster extent cutoff: based on GRFT ↑ L superior parietal
↑ L posterior inferior temporal gyrus/fusiform gyrus
↑ L occipital
Fridriksson et al. (2009):
Vox 3
Picture naming (semantic paraphasias) vs picture naming (correct trials) CB
Aphasia
NBD UNR Vox
C-
Search volume: voxels spared in all patients; software: FSL (FEAT 5.4); voxelwise p: ~.01 (z > 2.3); cluster extent cutoff: based on GRFT ↑ R posterior inferior temporal gyrus/fusiform gyrus
↑ R occipital
Skipper-Kallal et al. (2017b):
Vox 5
Picture naming (both phases, correct trials) vs picture naming (both phases, incorrect trials) CB
Aphasia with naming < 80% (n = 24)
NBD UNR Vox
C-
Search volume: whole brain gray matter; software: FSL 5.0.6; voxelwise p: ~.01 (z > 2.3); cluster extent cutoff: based on GRFT None
Pillay et al. (2018):
Vox 1
Reading nouns aloud (correct trials) vs reading nouns aloud (incorrect trials) CB
Aphasia
NBD Y Vox
CCS
Search volume: whole brain; software: AFNI; voxelwise p: .01; cluster extent cutoff: 1.609 cc; regarding correction for multiple comparisons, addition of monoexponential function reduces but does not eliminate inflation of p values (Cox et al., 2017) ↑ L angular gyrus
↓ L ventral precentral/inferior frontal junction
↓ L SMA/medial prefrontal
↓ R insula
↓ R ventral precentral/inferior frontal junction
↓ R SMA/medial prefrontal
notes: positive region (L AG) was part of the semantic network, while many negative regions were positively modulated by reaction time in the aphasia group

Second level contrast = Which of the 8 relevant classes of analyses is this? Which group or groups of participants are included? If there is a covariate, what is it?; Acc = Is accuracy matched across the second level contrast?; RT = Is reaction time matched across the second level contrast?; Stats = Does the analysis involve voxelwise statistics, region(s) of interest (ROI), or something else (complex)? If voxelwise, how are multiple comparisons across voxels accounted for? If ROI, were the ROI(s) anatomical, functional, laterality indices, mixed, or something else? If there was more than one ROI, how were the ROIs corrected for multiple comparions?; Yellow underline = minor limitation; Orange underline = moderate limitation; Red underline = major limitation; CB = Cross-sectional performance-defined conditions; Y = Yes, matched; NBD = No, by design; UNR = Unknown, not reported; Vox = Voxelwise; C- = Clusterwise correction with with GRFT and lenient voxelwise p; CCS = Clusterwise correction based on 3dClustSim.